血管周围间隙
脑脊液
薄壁组织
神经科学
神经退行性变
磁共振成像
医学
血管运动
脑淀粉样血管病
淀粉样β
病理
生物
内科学
疾病
痴呆
放射科
血管舒张
作者
Lydiane Hirschler,Bobby A. Runderkamp,Andreas Decker,Thijs W. van Harten,Paul Scheyhing,Philipp Ehses,Léonie Petitclerc,Julia Nordsiek,Eberhard Pracht,Bram F. Coolen,Wietske van der Zwaag,Tony Stoecker,Philipp Kickingereder,Daniel Paech,Alexander Effland,Marianne A.A. van Walderveen,Alexander Radbruch,Mark A. van Buchem,Gabor C. Petzold,Susanne J. van Veluw
标识
DOI:10.1038/s41593-025-02073-3
摘要
Abstract Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T 2 -prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.
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