Rosacea and Migraine: A Systematic Review and Meta‐Analysis Update

BACKGROUND: The association between rosacea and migraine is well-recognized, but the underlying mechanisms remain unclear. Emerging evidence suggests potential benefits of anti-migraine treatments for rosacea, highlighting the need for updated insights. This systematic review and meta-analysis assessed migraine prevalence in rosacea patients, compared it with non-rosacea populations, and explored influencing factors. METHODS: statistics, prediction intervals (PI), leave-one-out analyses, meta-regressions, and Baujat plots. RESULTS: = 98%; 95% PI, 0.67; 5.53), though the wide PI suggests that in some populations, the association may not be significant. CONCLUSIONS: Qualitative analysis identified erythematotelangiectatic subtype, female gender, age, and severity as potential contributing factors. However, inconsistencies across studies limit definitive conclusions. While we found high migraine prevalence and increased OR in rosacea patients, the substantial heterogeneity underscores the need for further stratification to enhance risk assessment and treatment strategies considering patient and population-level characteristics.