Accelerometer-based sleep metrics and gut microbiota during adolescence: Association findings from a Brazilian population-based birth cohort

肠道菌群 混淆 活动记录 睡眠(系统调用) 队列 队列研究 人口 微生物群 粪便 生物 医学 人口学 生理学 内科学 免疫学 生态学 环境卫生 生物信息学 昼夜节律 计算机科学 社会学 操作系统
作者
Marina Xavier Carpena,Aluísio J. D. Barros,Elena M. Comelli,Lorena López-Domínguez,Etiene Dias Alves,Andrea Wendt,Inácio Crochemore‐Silva,Robert Bandsma,Iná S. Santos,Alícia Matijasevich,Maria Carolina Borges,Luciana Tovo‐Rodrigues
出处
期刊:Sleep Medicine [Elsevier BV]
卷期号:114: 203-209 被引量:1
标识
DOI:10.1016/j.sleep.2023.12.028
摘要

Sleep and gut microbiota are emerging putative risk factors for several physical, mental, and cognitive conditions. Sleep deprivation has been shown to be linked with unhealthy microbiome environments in animal studies. However, in humans, the results are mixed. Epidemiological studies evaluating the effect of accelerometer-based sleep measures on gut microbiome are scarce. This study aims to explore the relationship between sleep duration and efficiency with the gut microbiota in adolescence. A subsample of 352 participants from the 2004 Pelotas (Brazil) Birth Cohort Study with sleep and fecal microbiota data available were included in the study. Sleep duration and sleep efficiency were obtained from actigraphy information at 11 years old whereas microbiota information from fecal samples was collected at 12 years. The fecal microbiota was analyzed via Illumina MiSeq (16S rRNA V3–V4 region) and the UNOISE pipeline. Alpha was assessed in QIIME2. Association measures for sleep variables and microbial α-diversity, and bacterial relative abundance were assessed through generalized models (linear and logistic regression), adjusting for maternal and child variables confounders. Adjusted models showed that sleep duration was positively associated with Simpson index of α-diversity (β = 0.003; CI95 %: 0.00004; 0.01). Both sleep duration (OR = 0.43; CI95 % 0.25; 0.74) and efficiency (OR = 0.55; CI95 % 0.38; 0.78) were associated with lower Bacteroidetes abundance. Our results suggest that sleep duration and efficiency are linked to gut microbiota diversity and composition even with 1–2 years gap from exposure to outcome. The findings support the role of sleep in the gut-brain axis as well as provide insights on how to improve microbiota health.
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