分子医学
自身免疫性胰腺炎
医学
癌基因
细胞周期
癌症
胰腺炎
内科学
作者
Vlad Pădureanu,Alice Nicoleta Drăgoescu,Rodica Pădureanu,Maria Magdalena Roșu,D Rădulescu,Dalia Dop,Mircea-Cătălin Forțofoiu
出处
期刊:Biomedical Reports
[Spandidos Publications]
日期:2023-12-21
卷期号:20 (2)
摘要
Autoimmune pancreatitis (AIP) is a rare disease. There are two distinct types of AIP: AIP type 1 (AIP-1), a pancreatic manifestation of a multi-organ disease linked to immunoglobulin (Ig)G4, and AIP type 2 (AIP-2), a pancreas-specific disease unrelated to IgG4. The usual course of treatment for AIP is oral corticosteroid medication. Rituximab has also been recommended for recurrent AIP-1 in order to initiate remission and provide ongoing treatment. Immunomodulators such as azathioprine are used to keep certain patients in remission. Evaluation also takes into account a number of pharmacological alternatives, including biologic drugs like anti-tumor necrosis factor therapy, a safe and efficient second-line treatment for AIP-2 relapse or steroid dependence. Corticosteroids and immunosuppressants, which are poorly tolerated due to considerable side effects, are being replaced by other biologic drugs, which may offer a beneficial therapeutic alternative.
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