单克隆抗体
免疫学
医学
抗体
CCR3
鼻粘膜
发病机制
过敏性炎症
炎症
鼻腔给药
免疫球蛋白E
趋化因子
趋化因子受体
作者
Youwei Bao,Zhonghang Wu,Xinhua Zhu,Jun Wu,Yinli Jiang,Ying Zhang,Yu Zhu,Zheng Liu,Danhui Yi,Wenqiang Liu,Mengyi Wei,Weiming Luo,Yong Xiao
标识
DOI:10.1038/s41598-024-51679-3
摘要
The pathogenesis of allergic asthma is similar to that of allergic rhinitis, with inflammation cells producing and releasing inflammatory mediators and cytokines closely related to CCR3.Based on the theory of "one airway, one disease", the use of CCR3 monoclonal antibody may have a similar effect on allergic rhinitis. However, there are few studies on CCR3 monoclonal antibody in allergic rhinitis. Therefore, the aim of this study was to investigate the effective concentration of CCR3 monoclonal antibody, to compare the effects of different methods of administration, and to examine the lung condition of allergic mice to investigate whether antibody treatment protects the lungs. In this study, we constructed a mouse model of allergic rhinitis and intraperitoneally injected different doses of CCR3 monoclonal antibody (5, 10, and 20 uL/mg) to observe its therapeutic effect: observing changes in tissue morphology of nasal mucosa, infiltration of inflammation, and using ELISA to detect changes in relevant inflammatory mediators and cytokines, studying the role of CCR3 mAb in inhibiting CCR3-related actions on the nasal mucosa of allergic rhinitis mice. Furthermore, In addition, the therapeutic effects of intraperitoneal injection (i.p.) and intranasal administration (i.n.) were studied on the basis of effective concentrations.
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