Chlorine Radical Mediated Deprotection of Aryl Ethers via Photocatalyzed Ligand‐to‐Metal Charge Transfer

Abstract A photochemical FeCl 3 ‐catalyzed the C( sp 3 )‐H activation of aryl ethers was achieved via hydrogen atom abstraction strategy of chlorine radicals. Followed by the tandem hydrolysis, the aryl ethers were converted into the corresponding phenol products (28 examples). Compared with traditional reductive deprotection methods for aryl ethers, such as Pd/C, Mg/alcohol system and so forth, our strategy features mild reaction conditions, atom economy, and wide functional group compatibility. In addition, several control experiments were conducted to investigate the reasonable mechanism.