CRISPR/Cas9‐mediated vitellogenin receptor knockout impairs vitellogenin uptake and reproduction in Bactrocera dorsalis

Collectively, these findings indicate that BdVgR plays a key role in the reproductive process in B. dorsalis, and that disrupting VgR function can inhibit egg production, leading to sterility, which highlights the potential that targeting VgR via CRISPR can create genetically sterile females. Data are discussed with regard to integration of a sterile insect technique approach in the design of novel, efficient and safe pest management tactics. © 2025 Society of Chemical Industry.