医学
头孢菌素
子宫内膜炎
青霉素
荟萃分析
泌尿系统
随机对照试验
抗生素
科克伦图书馆
广谱
内科学
重症监护医学
怀孕
微生物学
化学
生物
组合化学
遗传学
作者
Qianqian Song,Jingjing Yan,Na Bu,Ying Qian
标识
DOI:10.1080/01443615.2023.2195946
摘要
This study assessed the efficacy and safety between broad spectrum penicillin (P2) with or without beta-lactamase inhibitors (P2+) versus first and second generation cephalosporins (C1&C2) in the prevention of post-cesarean infections. Relevant randomized controlled trials (RCTs) were searched in English and Chinese databases: nine RCTs were involved. Six trials compared P2+ vs C1&C2, no differences were found between interventions for endometritis, wound infection, urinary tract infection, febrile morbidity and maternal rashes. Four trials compared P2 vs C1&C2, no differences were found between interventions for endometritis, febrile morbidity, wound infection and urinary tract infection. Postoperative hospitalization was longer for women in P2 than C1&C2. Based on these results, P2/P2+ and C1&C2 may have similar efficacy on postoperative infections after cesarean section, there is no data on infant outcomes. PROSPERO Registration Number: CRD42022345721.
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