生物材料
药物输送
复合数
组织工程
再生(生物学)
生物医学工程
骨组织
材料科学
骨愈合
脚手架
人骨
化学
纳米技术
复合材料
医学
外科
生物化学
细胞生物学
生物
体外
作者
Xiaojing Mo,Dianjian Zhang,Keda Liu,Xin Zhao,Xiaoming Li,Wei Wang
摘要
Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry and is, therefore, widely used as bone biomaterial and a drug carrier. Further, n-HAp composite scaffolds have a great potential role in bone regeneration. Loading bioactive factors and drugs onto n-HAp composites has emerged as a promising strategy for bone defect repair in bone tissue engineering. With local delivery of bioactive agents and drugs, biological materials may be provided with the biological activity they lack to improve bone regeneration. This review summarizes classification of n-HAp composites, application of n-HAp composite scaffolds loaded with bioactive factors and drugs in bone tissue engineering and the drug loading methods of n-HAp composite scaffolds, and the research direction of n-HAp composite scaffolds in the future is prospected.
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