磺胺噻唑
2型糖尿病
糖尿病
内分泌系统
医学
2型糖尿病
二甲双胍
药理学
药品
内分泌学
内科学
化学
激素
有机化学
作者
Zhuozhou Hu,Chun Li,Tongyu Wu,Jing Zhou,Liang Han,Jingjing Liu,Shaojia Qiang,Wenyang Zhao,Xiangxiang Li,Xiaohua Liu,Jiazhong Li,Xinping Chen
标识
DOI:10.1016/j.bbagen.2023.130303
摘要
Globally, diabetes mellitus has been a major epidemic bringing metabolic and endocrine disorders. Currently, 1 in 11 adults suffers from diabetes mellitus, among the patients >90% contract type 2 diabetes mellitus (T2DM). Therefore, it is urgent to develop new drugs that effectively prevent and treat type 2 diabetes through new targets. With high-throughput screening, we found that sulfathiazole decreased the blood glucose and improved glucose metabolism in T2DM mice. Notably, we discovered that sulfathiazole treated T2DM by activating CYP19A1 protein to synthesize estrogen. Collectively, sulfathiazole along with CYP19A1 target bring new promise for the better therapy of T2DM.
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