医学
巨细胞病毒
巨细胞病毒感染
造血干细胞移植
免疫学
免疫疗法
重症监护医学
移植
免疫系统
人类免疫缺陷病毒(HIV)
病毒性疾病
人巨细胞病毒
内科学
病毒
疱疹病毒科
作者
Yuqian Sun,Rui Ma,Xiao‐Jun Huang
标识
DOI:10.1080/1744666x.2023.2161510
摘要
Cytomegalovirus (CMV) infection continues to negatively impact the prognosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT), even with active monitoring and preemptive strategies. Recent progress in pharmacology, immunotherapy, and vaccines has improved the strategy of CMV management.We summarized recent advances in managing CMV infection post allo-HSCT, including diagnosis, prophylaxis, and treatment. In this review, we mainly focused on approaches that have optimized or might optimize the management of CMV infection after allo-HSCT.In our opinion, optimized management covers aspects including the serial monitoring of CMV-DNA and CMI, an accurate diagnosis, effective prophylaxis, and a rational preemptive therapy integrating antiviral drugs and cell therapies. Strategies based on the understanding of CMV pathogenesis and CMV-related immune reconstitution after allo-HSCT will be a direction in future studies.
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