蛋白质降解
模块化设计
计算生物学
蛋白质水解
降级(电信)
泛素连接酶
计算机科学
泛素
生化工程
生物
工程类
细胞生物学
生物化学
基因
操作系统
酶
电信
作者
Nathan L. Tran,Georges A. Leconte,Fleur M. Ferguson
摘要
Targeted protein degradation has recently gained widespread interest as both a novel therapeutic strategy and a useful tool in biomedical research. Targeted protein degraders are often sub-stoichiometric and do not require strong binding affinity for their targets, enabling access to previously inaccessible targets. Proteolysis-targeting chimeras (PROTACs) are one class of targeted protein degraders that promote degradation by recruiting a target protein to an E3-ligase complex via a heterobifunctional molecule. The modular nature of PROTACs allows for their rational design and systematic optimization. Here we suggest resources and methodologies for developing PROTAC degraders for researchers that may be new to the field. © 2022 Wiley Periodicals LLC.
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