Inhibition of SENP5 reduces brain injury in TBI rats by regulating NEDD4L/TCF3 axis

This study reveals that inhibiting SENP5 can alleviate brain injury following TBI. NEDD4L/TCF3 axis can regulate the expression of SENP5 to affect the development of TBI. However, SENP5 regulates downstream targets of TBI and important mechanisms need to be further explored.