血糖性
医学
糖尿病
内科学
流式细胞术
1型糖尿病
细胞
T细胞
内分泌学
胰岛素抵抗
2型糖尿病
2型糖尿病
混淆
免疫学
胃肠病学
免疫系统
生物
遗传学
作者
Qiang Sun,Ping Yang,Qing-Wei Gu,Weijun Gu,Wei Wang,Jie Wang,Xiao‐Ming Mao
标识
DOI:10.1016/j.jdiacomp.2024.108738
摘要
We aimed to investigate the association between glycemic variability (GV) and the abnormal differentiation of T-cell subpopulations in patients with type 2 diabetes mellitus (T2DM). In total, 108 hospitalized patients with T2DM were enrolled and divided into two subgroups (normal glycemic excursion (NGE) and high glycemic excursion (HGE)) according to their mean amplitude of glycemic excursion (MAGE) level. The MAGE was evaluated via continuous glucose monitoring for 72 h consecutively. Flow cytometry was used to determine the proportions of T cell subpopulations. The T helper (Th) 1 cell/Th2 cell ratio was significantly higher, and the proportion of regulatory T cells (Tregs) was significantly lower in the NGE group than in the HGE group (all P < 0.05). After fully adjusting for confounders, the MAGE was positively associated with the Th1 cell/Th2 cell ratio (β = 0.370; P = 0.009) and negatively associated with the proportion of Tregs (β = −0.554; P = 0.001). The MAGE was an independent risk factor for abnormally high Th1 cell/Th2 cell ratio and proportion of Tregs. Abnormal differentiation of T cell subpopulations induced by GV may impair β-cell function, aggravate insulin resistance, and contribute to the development of diabetic complications.
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