A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation

The Fe 3+ , Cu 2+ , or Zn 2+ associated amyloid β peptide (Aβ) aggregation is accountable for cellular toxicity in Alzheimer’s disease. Herein, a taurine-containing adaptable metal-sequestering peptide (AMSP) is developed to modulate such aggregation.