生物
猿猴
病毒学
灵长类动物
非洲绿猴
病毒
汉坦病毒
埃博拉病毒
拉沙热
病毒复制
猿猴免疫缺陷病毒
病毒性出血热
拉沙病毒
免疫学
汉坦病毒肺综合征
神经科学
作者
Cody J. Warren,Shuiqing Yu,Douglas K. Peters,Arturo Barbachano-Guerrero,Qing Yang,Bridget L. Burris,Gabriella Worwa,I-Chueh Huang,Gregory K. Wilkerson,Tony L. Goldberg,Jens H. Kuhn,Sara L. Sawyer
出处
期刊:Cell
[Elsevier]
日期:2022-09-01
卷期号:185 (21): 3980-3991.e18
被引量:4
标识
DOI:10.1016/j.cell.2022.09.022
摘要
Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic fevers when they cross into primate hosts of new species. We find that CD163 acts as an intracellular receptor for simian hemorrhagic fever virus (SHFV; a simian arterivirus), a rare mode of virus entry that is shared with other hemorrhagic fever-causing viruses (e.g., Ebola and Lassa viruses). Further, SHFV enters and replicates in human monocytes, indicating full functionality of all of the human cellular proteins required for viral replication. Thus, simian arteriviruses in nature may not require major adaptations to the human host. Given that at least three distinct simian arteriviruses have caused fatal infections in captive macaques after host-switching, and that humans are immunologically naive to this family of viruses, development of serology tests for human surveillance should be a priority.
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