生物
EZH2型
癌症研究
淋巴瘤
DNA复制因子CDT1
染色质
基因
增殖细胞核抗原
基因组不稳定性
DNA复制
细胞生长
遗传学
DNA
DNA损伤
免疫学
真核细胞DNA复制
作者
Katarina Horvat Pavlov,Vanja Tadić,Pamela Bašić Palković,Biljana Sasi,Nives Magdić,Matea Zajc Petranović,Marija Klasić,Suzana Hančić,Paula Gršković,Maja Matulić,Slavko Gašparov,Mara Dominis,Petra Korać
标识
DOI:10.1016/j.prp.2022.154170
摘要
Tumour cells develop by accumulating changes in the genome that result in changes of main cellular processes. Aberrations of basic processes such as replication and chromatin reassembly are particularly important for genomic (in)stability. The aim of this study was to analyse the expression of genes whose products are crucial for the regulation of replication and chromatin reassembly during lymphomagenesis (DNMT1, PCNA, MCM2, CDT1, EZH2, GMNN, EP300). Non-tumour B cells were used as a control, and follicular lymphoma (FL) and the two most common groups of diffuse large B cell lymphoma (DLBCL) samples were used as a model for tumour progression. The results showed that there are significant changes in the expression of the analysed genes in lymphomagenesis, but also that these changes do not display linearity when assessed in relation to the degree of tumour aggression. Additionally, an integrated bioinformatics analysis of the difference in the expression of selected genes between tumour and non-tumour samples, and between tumour samples (FL vs. DLBCL) in five GEO datasets, did not show a consistent pattern of difference among the datasets.
科研通智能强力驱动
Strongly Powered by AbleSci AI