微气泡
药物输送
纳米颗粒
血脑屏障
超声波
纳米技术
靶向给药
毒品携带者
药物输送到大脑
中枢神经系统
化学
生物医学工程
材料科学
医学
神经科学
心理学
放射科
作者
Andreas Åslund,Sigrid Berg,Sjoerd Hak,Ýrr Mørch,Sverre Helge Torp,Axel Sandvig,Marius Widerøe,Rune Hansen,Catharina de Lange Davies
标识
DOI:10.1016/j.jconrel.2015.10.047
摘要
The blood-brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug delivery across the BBB. Furthermore, focused ultrasound in combination with gas filled microbubbles has opened the BBB in a temporospatial manner in animal models, thus facilitating drug delivery across the BBB. In the current study we combine these two approaches in our quest to develop a novel, generic method for drug delivery across the BBB and into the CNS. Nanoparticles were synthesized using the polymer poly(butyl cyanoacrylate) (PBCA), and such nanoparticles have been reported to cross the BBB to some extent. Together with proteins, these nanoparticles self-assemble into microbubbles. Using these novel microbubbles in combination with focused ultrasound, we successfully and safely opened the BBB transiently in healthy rats. Furthermore, we also demonstrated that the nanoparticles could cross the BBB and deliver a model drug into the CNS.
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