生物催化
化学选择性
有机合成
生化工程
试剂
催化作用
化学
有机化学
纳米技术
计算机科学
组合化学
材料科学
反应机理
工程类
作者
Christoph Winkler,Joerg H. Schrittwieser,Wolfgang Kroutil
出处
期刊:ACS central science
[American Chemical Society]
日期:2021-01-14
卷期号:7 (1): 55-71
被引量:186
标识
DOI:10.1021/acscentsci.0c01496
摘要
Biocatalysis, using defined enzymes for organic transformations, has become a common tool in organic synthesis, which is also frequently applied in industry. The generally high activity and outstanding stereo-, regio-, and chemoselectivity observed in many biotransformations are the result of a precise control of the reaction in the active site of the biocatalyst. This control is achieved by exact positioning of the reagents relative to each other in a fine-tuned 3D environment, by specific activating interactions between reagents and the protein, and by subtle movements of the catalyst. Enzyme engineering enables one to adapt the catalyst to the desired reaction and process. A well-filled biocatalytic toolbox is ready to be used for various reactions. Providing nonnatural reagents and conditions and evolving biocatalysts enables one to play with the myriad of options for creating novel transformations and thereby opening new, short pathways to desired target molecules. Combining several biocatalysts in one pot to perform several reactions concurrently increases the efficiency of biocatalysis even further.
科研通智能强力驱动
Strongly Powered by AbleSci AI