眼内炎
光动力疗法
绿脓素
医学
体内
表皮葡萄球菌
生物相容性
微生物学
光敏剂
铜绿假单胞菌
化学
抗菌剂
生物膜
金黄色葡萄球菌
细菌
生物
眼科
有机化学
生物技术
群体感应
遗传学
作者
Yingying Jin,Yuqin Wang,Jie Yang,Hengrui Zhang,Ying‐Wei Yang,Wei Chen,Wenya Jiang,Jia Qu,Yishun Guo,Bailiang Wang
标识
DOI:10.1016/j.xcrp.2020.100173
摘要
Infectious endophthalmitis is a growing concern that causes irreversible intraocular tissue and optic nerve damage. Here, we report a theranostic nanoplatform based on UiO-66-NH2 to combine photodynamic therapy (PDT) and lipopolysaccharide (LPS) targeting through polypeptide (YVLWKRKRKFCFI-NH2) modification. Toluidine blue (TB), serving as a photosensitizer (PS), is loaded into UiO-66-NH2 nanoparticles (NPs) for both self-imaging and PDT functions. The accelerated TB release at pH 5.5 compared to pH 7.4 demonstrates the responsive drug release feature. In vitro antibacterial tests, including contact incubation-agar plate counting, bacterial live/dead staining, and scanning electron microscopy observations, confirm the utility of the [email protected]2@PEP&PEG NPs (UTPP NPs) in biofilms removal and sterilization of Pseudomonas aeruginosa and Staphylococcus epidermidis. Furthermore, the UTPP NPs also show good biocompatibility toward human retinal pigment epithelial cells, as well as in situ self-imaging property. Finally, an in vivo infectious endophthalmitis model supports the application of the UTPP NPs in infectious endophthalmitis treatment.
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