Four decades of progress in cylindrospermopsin research: The ins and outs of a potent cyanotoxin

The cyanotoxin cylindrospermopsin (CYN), a toxic metabolite from cyanobacteria, is of particular concern due to its cosmopolitan occurrence, aquatic bioaccumulation, and multi-organ toxicity. CYN is the second most often recorded cyanotoxin worldwide, and cases of human morbidity and animal mortality are associated with ingestion of CYN contaminated water. The toxin poses a great challenge for drinking water treatment plants and public health authorities. CYN, with the major toxicity manifested in the liver, is cytotoxic, genotoxic, immunotoxic, neurotoxic and may be carcinogenic. Adverse effects are also reported for endocrine and developmental processes. We present a comprehensive review of CYN over the past four decades since its first reported poisoning event, highlighting its global occurrence, biosynthesis, toxicology, removal, and monitoring. In addition, current data gaps are identified, and future directions for CYN research are outlined. This review is beneficial for understanding the ins and outs of this environmental pollutant, and for robustly assessing health hazards posed by CYN exposure to humans and other organisms. • Information on aquatic occurrence of CYN is updated from a global perspective. • Few environmental data of CYN are available for South America and Africa. • The mode of CYN action and hypothesized toxicological pathways are delineated. • Photo-, bio-degradation and physicochemical removal techniques of CYN are evaluated. • Emerging biosensor devices are promising for on-site and real-time monitoring of CYN.