Endodontics is an image-guided treatment and, until recently, has been restricted to in-office periapical (PA) and panoramic radiographic assessments. Cone beam computed tomography (CBCT), allows for the three-dimensional assessment of the craniofacial complex for the visualization of pathologic alterations and anatomic structures without errors due to anatomic superimpositions, resulting in a significant reduction of false-negative results. Two-dimensional radiographic imaging is still one of the most commonly used diagnostic tools in endodontics, although many studies have shown that interpretation of changes in the root-supporting structures is not reliable. This chapter discusses the applications of CBCT in endodontics. The chapter concludes with a discussion on the assessment of endodontic treatment outcomes.