A Comparison of Metronidazole Distribution Following Intravenous Metronidazole and Metronidazole Phosphate Disodium in Mice

The distribution of metronidazole following intravenous metronidazole (MTZ) and metronidazole phosphate disodium (MNP) in mice was investigated by HPLC. The results showed no significant differences in the metronidazole concentrations of liver, kidney, heart, spleen, fat, brain, lung, stomach, jejunum, skeletal muscle, ovary, testis and epididymis (P greater than 0.05). It can be concluded that using MNP as a water-soluble substitute for MTZ should not influence the distribution of metronidazole in mice.