吞噬体
生物
细胞生物学
抗原
抗原处理
NADPH氧化酶
蛋白酵素
抗原呈递
树突状细胞
免疫系统
抗原提呈细胞
细胞毒性T细胞
微生物学
吞噬作用
免疫学
T细胞
活性氧
生物化学
体外
酶
作者
Ariel Savina,Carolina Jancic,Stéphanie Hugues,Pierre Guermonprez,Pablo Agustín Vargas,Ivan C. Moura,Ana-María Lennon-Duménil,Miguel C. Seabra,Graça Raposo,Sebastián Amigorena
出处
期刊:Cell
[Elsevier]
日期:2006-07-01
卷期号:126 (1): 205-218
被引量:772
标识
DOI:10.1016/j.cell.2006.05.035
摘要
To initiate adaptative cytotoxic immune responses, proteolytic peptides derived from phagocytosed antigens are presented by dendritic cells (DCs) to CD8+ T lymphocytes through a process called antigen "crosspresentation." The partial degradation of antigens mediated by lysosomal proteases in an acidic environment must be tightly controlled to prevent destruction of potential peptides for T cell recognition. We now describe a specialization of the phagocytic pathway of DCs that allows a fine control of antigen processing. The NADPH oxidase NOX2 is recruited to the DC's early phagosomes and mediates the sustained production of low levels of reactive oxygen species, causing active and maintained alkalinization of the phagosomal lumen. DCs lacking NOX2 show enhanced phagosomal acidification and increased antigen degradation, resulting in impaired crosspresentation. Therefore, NOX2 plays a critical role in conferring DCs the ability to function as specialized phagocytes adapted to process antigens rather than kill pathogens.
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