新生内膜
血小板源性生长因子受体
发病机制
生长因子
血小板衍生生长因子
细胞外基质
病变
细胞生长
生物
血管平滑肌
疾病
细胞生物学
免疫学
病理
癌症研究
医学
平滑肌
内科学
内分泌学
再狭窄
遗传学
受体
支架
标识
DOI:10.1016/j.cytogfr.2004.03.004
摘要
Platelet-derived growth factor (PDGF) was identified in a search for serum factors that stimulate smooth muscle cell (SMC) proliferation. During the development of lesions of atherosclerosis that can ultimately lead to vessel occlusion, SMC are stimulated by inflammatory factors to migrate from their normal location in the media. They accumulate within the forming lesion where they contribute to lesion expansion by proliferation and deposition of extracellular matrix. Different genetic manipulations in vascular cells combined with various inhibitory strategies have provided strong evidence for PDGF playing a prominent role in the migration of SMC into the neointima following acute injury and in atherosclerosis. Other activities of PDGF identified in vivo suggest additional functions for PDGF in the pathogenesis of cardiovascular disease.
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