化学
癌症
癌细胞系
苯并呋喃
组合化学
芳基
癌细胞
缩合反应
立体化学
有机化学
医学
催化作用
烷基
内科学
作者
Şeref Demirayak,Leyla Yurttaş,Nalan Gündoğdu-Karaburun,Ahmet Çağrı Karaburun,İsmail Kayağil
标识
DOI:10.3109/14756366.2014.976568
摘要
In this study, we have synthesized 2-[3- or 4-(2-aryl-2-oxoethoxy)arylidene]benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions using benzofuranon-3-one derivatives (A1-A4, B) as starting materials which were gained in various synthetic ways. Aurone derivatives (C1-C10) were acquired with the condensation reaction of these starting materials and 3-/4-hydroxybenzaldehyde which were then reacted with α-bromoacetophenones to get final compounds. The anti-cancer activity of the selected compounds was performed by National Cancer Institute (NCI), USA against 60 human tumor cell lines derived from nine neoplastic diseases. Compounds exhibited anti-cancer activity in varying ratios.
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