免疫系统
细菌
生物
胃肠道
免疫学
疾病
微生物学
肠道细菌
微生物群
发病机制
医学
生物信息学
遗传学
内科学
生物化学
作者
Nobuhiko Kamada,Gabriel Núñez
标识
DOI:10.1053/j.gastro.2014.01.060
摘要
The microbiota is an important factor in the development of the immune response. The interaction between the gastrointestinal tract and resident microbiota is well balanced in healthy individuals, but its breakdown can lead to intestinal and extraintestinal disease. We review current knowledge about the mechanisms that regulate the interaction between the immune system and the microbiota, focusing on the role of resident intestinal bacteria in the development of immune responses. We also discuss mechanisms that prevent immune responses against resident bacteria, and how the indigenous bacteria stimulate the immune system to protect against commensal pathobionts and exogenous pathogens. Unraveling the complex interactions between resident intestinal bacteria and the immune system could improve our understanding of disease pathogenesis and lead to new therapeutic approaches.
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