神经科学
磁刺激
神经调节
刺激
脑刺激
脑功能
医学
癫痫
经颅交流电刺激
大脑活动与冥想
神经影像学
脑深部刺激
脑电图
经颅直流电刺激
心理学
病理
疾病
帕金森病
作者
Yusuf Tufail,Anna Yoshihiro,Sandipan Pati,Monica M. Li,William J. Tyler
出处
期刊:Nature Protocols
[Springer Nature]
日期:2011-09-01
卷期号:6 (9): 1453-1470
被引量:364
标识
DOI:10.1038/nprot.2011.371
摘要
Brain stimulation methods are indispensable to the study of brain function. They have also proven effective for treating some neurological disorders. Historically used for medical imaging, ultrasound (US) has recently been shown to be capable of noninvasively stimulating brain activity. Here we provide a general protocol for the stimulation of intact mouse brain circuits using transcranial US, and, using a traditional mouse model of epilepsy, we describe how to use transcranial US to disrupt electrographic seizure activity. The advantages of US for brain stimulation are that it does not necessitate surgery or genetic alteration, but it confers spatial resolutions superior to other noninvasive methods such as transcranial magnetic stimulation. With a basic working knowledge of electrophysiology, and after an initial setup, ultrasonic neuromodulation (UNMOD) can be implemented in less than 1 h. Using the general protocol that we describe, UNMOD can be readily adapted to support a broad range of studies on brain circuit function and dysfunction.
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