细胞生物学
细胞毒性T细胞
抗原呈递
交叉展示
抗原
抗原处理
MHC I级
内吞循环
抗原提呈细胞
胞浆
生物
免疫系统
主要组织相容性复合体
CD1型
内体
内吞作用
T细胞
免疫学
细胞
生物化学
体外
细胞内
酶
作者
Ana Rodrı́guez,Armelle Régnault,Monique J. Kleijmeer,Paola Ricciardi‐Castagnoli,Sebastián Amigorena
摘要
In order for cytotoxic T cells to initiate immune responses, peptides derived from internalized antigens must be presented to the cytotoxic T cells on major histocompatibility complex (MHC) class I molecules. Here we show that dendritic cells, the only antigen-presenting cells that initiate immune responses efficiently, have developed a unique membrane transport pathway linking the lumen of endocytic compartments and the cytosol. Endosome-to-cytosol transport is restricted to dendritic cells, specific to internalized antigens and selective for the size of the transported molecules. Thus, in dendritic cells, internalized antigens gain access to the cytosolic antigen-processing machinery and to the conventional MHC class I antigen-presentation pathway.
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