骨桥蛋白                        
                
                                
                        
                            CD44细胞                        
                
                                
                        
                            细胞生物学                        
                
                                
                        
                            整合素                        
                
                                
                        
                            信号转导                        
                
                                
                        
                            生物                        
                
                                
                        
                            化学                        
                
                                
                        
                            毒物                        
                
                                
                        
                            受体                        
                
                                
                        
                            癌症研究                        
                
                                
                        
                            细胞                        
                
                                
                        
                            免疫学                        
                
                                
                        
                            生物化学                        
                
                                
                        
                            毒性                        
                
                                
                        
                            有机化学                        
                
                        
                    
            作者
            
                David T. Denhardt,Cecilia M. Giachelli,Susan R. Rittling            
         
                    
        
    
            
            标识
            
                                    DOI:10.1146/annurev.pharmtox.41.1.723
                                    
                                
                                 
         
        
                
            摘要
            
            Osteopontin (OPN) is a glycosylated phosphoprotein found in all body fluids and in the proteinaceous matrix of mineralized tissues. It can function both as a cell attachment protein and as a cytokine, delivering signals to cells via a number of receptors including several integrins and CD44. Expression of OPN is enhanced by a variety of toxicants, especially those that activate protein kinase C. In its capacity as a signaling molecule, OPN can modify gene expression and promote the migration of monocytes/macrophages up an OPN gradient. It has both inflammatory and anti-inflammatory actions. Some experiments suggest that it may inhibit apoptosis, possibly contributing to the survival of cells in response to toxicant injury. Elevated OPN expression often correlates with malignancy and has been shown to enhance the tumorigenic and/or metastatic phenotype of the cancer cell. Recent studies have revealed that OPN plays critical roles in bone remodeling and cell-mediated immunity.
         
            
 
                 
                
                    
                    科研通智能强力驱动
Strongly Powered by AbleSci AI