医学
多器官功能障碍综合征
器官功能障碍
发病机制
神经科学
免疫学
细胞因子
生物信息学
生物
败血症
作者
Paul Godin,Timothy G. Buchman
标识
DOI:10.1097/00003246-199607000-00008
摘要
To present a complementary hypothesis concerning the pathogenesis of the multiple organ dysfunction syndrome.Primary reports and reviews published in peer-reviewed medical and scientific journals.We suggest that healthy organs behave as biological oscillators, which couple to one another during human development, and that this orderly coupling is maintained through a communications network, including neural, humoral, and cytokine components. We suggest that the systemic inflammatory response syndrome initiates disruption of communication and uncoupling, and further suggest that progression into the multiple organ dysfunction syndrome reflects progressive uncoupling that can become irreversible. Resolution of the inflammatory response and reestablishment of the communications network are necessary but may not be, by itself, sufficient to allow organs to appropriately recouple. This hypothesis is testable using existing laboratory and clinical tools.
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