生物
胚胎干细胞
干细胞
细胞分化
发育生物学
干细胞生物学
再生医学
计算生物学
细胞疗法
细胞
细胞生物学
遗传学
基因
胚胎发生
胚胎
生殖技术
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2005-05-15
卷期号:19 (10): 1129-1155
被引量:1096
摘要
The discovery of mouse embryonic stem (ES) cells >20 years ago represented a major advance in biology and experimental medicine, as it enabled the routine manipulation of the mouse genome. Along with the capacity to induce genetic modifications, ES cells provided the basis for establishing an in vitro model of early mammalian development and represented a putative new source of differentiated cell types for cell replacement therapy. While ES cells have been used extensively for creating mouse mutants for more than a decade, their application as a model for developmental biology has been limited and their use in cell replacement therapy remains a goal for many in the field. Recent advances in our understanding of ES cell differentiation, detailed in this review, have provided new insights essential for establishing ES cell-based developmental models and for the generation of clinically relevant populations for cell therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI