Tree shrew immune cell atlas identifies NR1H3⁺ tissue macrophages with conserved anti-inflammatory function

macrophage gene programmes are evolutionarily conserved. Functional analyses further support a shared anti-inflammatory programme mediated by NR1H3-dependent suppression of the non-canonical NF-κB pathway in both tree shrew and human macrophages. Together, these findings provide a reference resource for tree shrew immunology and support the tree shrew as a complementary model alongside rodent and primate systems.