免疫系统
医学
胰腺癌
癌症研究
抑制器
癌症
免疫学
疾病
胰腺导管腺癌
信号转导
细胞因子
作者
Lingxing Zeng,S. Liu,Xinyi Peng,Chunling Xue,D. Wang,Ruihong Bai,Shaoqiu Liu,Ziming Chen,Hongzhe Zhao,Zilan Xu,Sihan Zhao,Y. Zhou,Xiaoyu Wu,Shaojia Wu,Mei Li,Ji Liu,Jialiang Zhang,Qi Zhou,Xudong Huang,Jiachun Su
出处
期刊:PubMed
日期:2026-01-22
标识
DOI:10.1136/gutjnl-2025-336541
摘要
NSUN6 deficiency drives immune suppression through the m5C-KDM5A-CCL2 axis in PDAC. Targeting the NSUN6-CCL2 axis represents a promising strategy to sensitise PDAC to ICB therapy.
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