The aim of this research is a comprehensive analysis of the impact of artificial intelligence (AI) integration on employee well-being and burnout levels. The theoretical part presents an integrated model based on five conceptual frameworks (JD-R, Technostress, Boundary, COR, and Role Conflict) to analyse the dual impact of AI. The practical part, based on a mixed-method study of respondents from Nigeria and Russia, empirically proves that trust in AI fully mediates the relationship between AI integration and professional burnout, acting as a key protective factor. The project part also reveals that organizational policy transparency has partial significance. In conclusion, the study confirms the mediating role of trust, identifies cross-cultural differences, and provides evidence-based business processes with templates and KPIs for implementing a human-cantered approach to AI.