疾病
帕金森病
情感(语言学)
心理干预
医学
机制(生物学)
风险因素
老年学
心理学
内科学
精神科
沟通
认识论
哲学
作者
Silvia Cerri,Liudmila Mus,Fabio Blandini
出处
期刊:Journal of Parkinson's disease
[IOS Press]
日期:2019-07-30
卷期号:9 (3): 501-515
被引量:261
摘要
Increasing evidence points to biological sex as an important factor in the development and phenotypical expression of Parkinson's disease (PD). Risk of developing PD is twice as high in men than women, but women have a higher mortality rate and faster progression of the disease. Moreover, motor and nonmotor symptoms, response to treatments and disease risk factors differ between women and men. Altogether, sex-related differences in PD support the idea that disease development might involve distinct pathogenic mechanisms (or the same mechanism but in a different way) in male and female patients. This review summarizes the most recent knowledge concerning differences between women and men in PD clinical features, risk factors, response to treatments and mechanisms underlying the disease pathophysiology. Unraveling how the pathology differently affect the two sexes might allow the development of tailored interventions and the design of innovative programs that meet the distinct needs of men and women, improving patient care.
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