微粉化
药物输送
材料科学
纳米技术
微载波
药品
靶向给药
涂层
化学工程
化学
药理学
粒径
医学
生物化学
工程类
细胞
作者
Hongdi Wang,Xiaolin Zhang,Zhu Wang,Yanbin Jiang,Zhibing Zhang
标识
DOI:10.1021/acs.iecr.8b02092
摘要
The advances in pharmaceutical technology allow for the development of various region-selective delivery systems for oral administration to optimize local and systemic therapy. In this paper, micronization associated with a polymorph modification approach was proposed for improving the solubility of hydrophobic drugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or intermolecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release.
科研通智能强力驱动
Strongly Powered by AbleSci AI