表观遗传学
跨代表观遗传学
后生
生物
遗传(遗传算法)
DNA甲基化
疾病
遗传学
进化生物学
基因
计算生物学
医学
病理
基因表达
作者
Giacomo Cavalli,Édith Heard
出处
期刊:Nature
[Springer Nature]
日期:2019-07-01
卷期号:571 (7766): 489-499
被引量:1037
标识
DOI:10.1038/s41586-019-1411-0
摘要
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified excitement and hope, but also a degree of hype. Here we review how the field has evolved over the last few decades and reflect on some of the recent advances that are changing our understanding of biology. We discuss the interplay between epigenetics and DNA sequence variation as well as the implications of epigenetics for cellular memory and plasticity. We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. Finally, we present some new frontiers in epigenetics with implications for human health. The authors review recent advances and current debates in epigenetics, including how epigenetic mechanisms interact with genetic variation, ageing, disease and the environment.
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