甲状腺机能正常
内科学
医学
内分泌学
心房颤动
甲状腺功能
激素
甲状腺
血浆水平
心脏病学
作者
Fadia Mayyas,Nesreen Saadeh,Kusai M. Al-Muqbel,David R. Van Wagoner
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2018-12-04
卷期号:13 (12): e0208206-e0208206
被引量:7
标识
DOI:10.1371/journal.pone.0208206
摘要
Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.The present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status.Blood samples from euthyroid patients (n = 41), hypothyroid (n = 61), hyperthyroid (n = 41), AF with hyperthyroidism (n = 9), and euthyroid AF (n = 10) patients were collected. Plasma ET-1, CRP, and thyroid hormone levels were measured and compared between groups.Plasma ET-1 levels were higher in hyperthyroid and euthyroid AF patients> hyperthyroid-non-AF > hypo and euthyroid non-AF patients. Plasma ET-1 levels positively correlated with free T3 and T4 levels, and negatively with TSH levels. By multivariate analysis, plasma ET-1 was positively associated with AF, hyperthyroidism, and age. Plasma CRP did not vary by study group in either univariate or multivariate analyses.Plasma ET-1 is associated with AF, elevated in hyperthyroid patients and positively correlated with thyroid hormone levels, suggesting that hyperthyroidism may increase ET-1 expression and release. This study may guide development of novel predictors of AF associated with hyperthyroidism, and may help to personalize therapy in hyperthyroid patients.
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