Precipitation of resveratrol-isoniazid and resveratrol-nicotinamide cocrystals by gas antisolvent

Over the last years, resveratrol (RES), a phytoalexin found in grape skin, has received more attention due to its properties antioxidant, anticancer, anti-inflammatory, antimicrobial and cardioprotective. However, its use in food has been limited due to its poor solubility, instability and low bioavailability. Thus, the aim of study was to prepare cocrystals of resveratrol to improve solubility and dissolution rate using gas antisolvent (GAS) technique. The resveratrol cocrystals were prepared using isoniazid (INZ) and nicotinamide (NIC) as coformer by supercritical CO2 as antisolvent through the gas antisolvent technique. The coformers were selected from previous screening using anti-solvent liquid. The cocrystals were characterized by field emission scanning electron microscope (FESEM), infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The RES-NIC cocrystal was evaluated in terms of dissolution rate, compared with resveratrol processed under the same conditions as the gas antisolvent.