ChemInform Abstract: Synthesis of Trifluoromethylated Pyrazine‐Containing Nitrogen Heterocycles from Trifluoropyruvaldehyde and ortho‐Diamines: Scope and Regiochemistry.

Abstract Hydrolysis of the trifluorodibromoacetone (II) and subsequent cyclocondensation with the primary diamines (I) or (IV) yield the quinoxaline derivatives (III) or a mixture of the isomeric trifluoromethylpteridinediones (V) and (VI).