姜黄素
热休克蛋白
热休克蛋白60
热休克蛋白27
血管生成
癌细胞
癌症研究
癌症
热休克蛋白70
运动性
转移
热休克蛋白90
生物
化学
细胞生物学
药理学
生物化学
基因
遗传学
作者
Fatemeh Forouzanfar,George E. Barreto,Muhammed Majeed,Amirhossein Sahebkar
出处
期刊:Biofactors
[Wiley]
日期:2019-05-28
卷期号:45 (5): 631-640
被引量:21
摘要
Abstract Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress‐inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.
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