the Effect of Potato (Solanum tuberosum L.) Skin Extract on Alkaline Phosphatase Level in Periodontitis

Periodontitis is a chronic inflammation on tooth supporting tissues leads to alveolar bone resorption and tooth loss. Increase of alkaline phosphatase (ALP) level is found in periodontitis condition. Potato skin extract is known for its antioxidant and antiinflammation compounds therefore presumably potential as adjuvant therapy for periodontitis. This study aim was to know the effect of oral intake of potato skin extract on alveolar bone ALP and serum ALP level in model periodontitis Sprague dawley rats. Type of the study was experimental with posttest-only control group design. Thirty-five male Sprague dawley rats were divided into five groups: healthy control, negative control (aquadest-treated periodontitis), and potato skin extract- treated periodontitis in three different concentrations (25%, 50%, 75%). After 14-day treatments, ALP level on alveolar bone and blood serum samples from each group were measured using UV-Vis spectrophotometer. The results showed both alveolar bone ALP and serum ALP level were lower in potato skin extract-treated periodontitis groups in comparison to negative control group. Statistic analysis using One-way Anova showed significant difference of ALP level amongst groups (p<0.05). Post-hoc LSD test showed significant differences of ALP level between each treated and control groups (p<0.05). This study concluded potato skin extract decreased ALP level, with concentration 75% showed lowest both ALP levels of alveolar bone and serum samples, indicated alveolar bone remodeling. Moreover, it is suggested that ALP level in serum can represent ALP level on alveolar bone tissues in periodontitis condition.