介子
嘧啶酮类
化学
药物发现
组合化学
生物活性
立体化学
计算生物学
体外
生物化学
有机化学
生物
作者
Wenming Zhang,C. W. Holyoke,Thomas F. Pahutski,George P. Lahm,James D. Barry,Daniel Cordova,Robert M. Leighty,Vineet Singh,Daniel R. Vicent,My-Hanh T. Tong,Kenneth A. Hughes,Stephen F. McCann,Yewande T. Henry,Ming Xu,Twyla A. Briddell
标识
DOI:10.1016/j.bmcl.2016.11.042
摘要
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program which led to the discovery of triflumezopyrim as a highly potent insecticide controlling various hopper species. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.
科研通智能强力驱动
Strongly Powered by AbleSci AI