International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma

多发性骨髓瘤 医学 微小残留病 骨髓 临床试验 骨髓瘤蛋白 单克隆 肿瘤科 残余物 内科学 疾病 单克隆抗体 免疫学 计算机科学 抗体 算法
作者
Shaji Kumar,Bruno Paiva,Kenneth C. Anderson,Brian G.M. Durie,Ola Landgren,Philippe Moreau,Nikhil C. Munshi,Sagar Lonial,Joan Bladé,María Victoria Mateos,Meletios Α. Dimopoulos,Mario Boccadoro,Robert Z. Orłowski,Hartmut Goldschmidt,Andrew Spencer,Jian Hou,Wee Joo Chng,Saad Z. Usmani,Elena Zamagni,Kazuyuki Shimizu,Sundar Jagannath,Hans Erik Johnsen,Evangelos Terpos,Anthony Reiman,Robert A. Kyle,Pieter Sonneveld,Paul G. Richardson,Philip L. McCarthy,Heinz Ludwig,Wen-Ming Chen,Michèle Cavo,Jean Luc Harousseau,Suzanne Lentzsch,Jens Hillengaß,Antônio Palumbo,Alberto Órfão,S. Vincent Rajkumar,Jesús F. San Miguel,Hervé Avet-Loiseau
出处
期刊:Lancet Oncology [Elsevier]
卷期号:17 (8): e328-e346 被引量:1827
标识
DOI:10.1016/s1470-2045(16)30206-6
摘要

Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments.
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