免疫学
先天免疫系统
效应器
背景(考古学)
炎症
生物
神经科学
趋化性
运动性
中性粒细胞胞外陷阱
细胞生物学
免疫系统
受体
生物化学
古生物学
作者
Sussan Nourshargh,Stephen A. Renshaw,Beat A. Imhof
标识
DOI:10.1016/j.it.2016.03.006
摘要
Neutrophil migration to injured and pathogen-infected tissues is a fundamental component of innate immunity. An array of cellular and molecular events mediate this response to collectively guide neutrophils out of the vasculature and towards the core of the ensuing inflammatory reaction where they exert effector functions. Advances in imaging modalities have revealed that neutrophils can also exhibit motility away from sites of inflammation and injury, although it is unclear under what circumstances this reverse migration is a physiological protective response, and when it has pathophysiological relevance. Here we review different types of neutrophil reverse migration and discuss the current understanding of the associated mechanisms. In this context we propose clarifications to the existing terminology used to describe the many facets of neutrophil reverse migration.
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