A lot of radioactive contamination will be produced in the nuclear fuel recycling process. At the same time, a number of nonradioactive materials will be found, such as heavy metals, organic mate- rial etc. The presence and interaction of these contaminants provide more challenge for sites remediation. Remediation of sites with mixed contamination is a difficult problem met in sites remediation. Several meth- ods and measures of remediation of sites with radioactive and nonradioactive contamination are introduced.