Predictive value of brain natriuretic peptide and copeptin levels in detecting coronary artery disease

Objective: To study the relationship between brain natriuretic peptide (BNP), copeptin levels and the degree of coronary artery disease (CAD) in patients with CAD. Method: 40 patients with acute myocardial infarction (AMI), 36 patients with unstable angina pectoris (UAP), 51 patients with stable angina pectoris (SAP) and 30 cases of healthy controls were selected. The correlations of the number of impaired coronary arteries (CA), left main coronary stenosis and Gensini scores of CA with levels of BNP and Copeptin were compared. Results: BNP and copeptin levels of AMI, UAP group were significantly higher than that of SAP and control group. BNP and copeptin levels of AMI were significantly higher than that of UAP group, the differences were statistically significant (P 0.05). BNP, copeptin levels and coronary lesion vessels, left main coronary stenosis, coronary Gensini score were positively correlated (P 0.05). Conclusion: BNP and copeptin levels reflect the severity of clinical symptoms and impaired coronary arteries of CAD patients.