Objective To observe the efficacy of tetramethylpyrazine combined with xuehuzhuyu decoction in the treatment of vertebrobasilar insufficiency(VBI).Methods Among the 120 VBI patients,60 were treated by of tetramethylpyrazine combined with xuehuzhuyu decoction,the others were treated by tetramethylpyrazine only.The clinical efficacy,hemorrheology,tanscranial doppler(TCD) were measured at one day before and after treatment for each case.Results A improvement of overall efficacy was observed in tetramethylpyrazine combined with xuehuzhuyu decoction group compared with tetramethylpyrazine group(93.33% vs 70.00% P0.05).Conclusion The combination of tetramethylpyrazine combined with xuehuzhuyu decoction was proved to be effective than that of tetramethylpyrazine in the treatment of VBI.