Regulation of Pituitary Gonadotrophic Secretion: Inhibition by Estrogen or Inactivation by the Ovaries?

By autotransplantation of both ovaries into the spleen of mature female rats, the ovary continues to be bathed by pituitary gonadotrophins but the pituitary is no longer bathed by estrogens because in essence the liver has been inserted between the ovaries and the pituitary and has inactivated the estrogens.